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Cell‐surface receptors: Puzzles and paradigms
Author(s) -
Geisow Michael J.
Publication year - 1986
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950040403
Subject(s) - asialoglycoprotein receptor , receptor , transferrin , transferrin receptor , cell surface receptor , epidermal growth factor , biology , microbiology and biotechnology , endocytosis , cell , antibody , biochemistry , insulin receptor , computational biology , insulin , immunology , endocrinology , insulin resistance , hepatocyte , in vitro
The determination of amino acid sequences representing the cell‐surface receptors for transferrin, 1 asialoglycoprotein, 2 polymeric immunoglobulin ( IgA/IgM ), 3 epidermal growth factor ( EGF ), 4 lowdensity lipoprotein ( LDL ) 5 and insulin 6 has produced new paradingms for receptor architecture. This review examines common features of the protiens and describes the intriguing functional and evolutionary puzzles that have arisen from them.