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Catalysis by RNA
Author(s) -
Waugh David S.,
Pace Norman R.
Publication year - 1986
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950040204
Subject(s) - ribozyme , tetrahymena , rnase p , rna , intron , transfer rna , rna splicing , biology , rna world hypothesis , ribosomal rna , post transcriptional modification , enzyme , rnase h , computational biology , biochemistry , genetics , gene
Until the discovery of catalytic RNA, the notion that all enzymes are proteins had seemed incontrovertible. Now the existence of RNA enzymes has been confirmed in a variety of contexts. What is known about the chemistry of RNA‐catalyzed reactions is reviewed below, with particular attention to the self‐splicing rRNA intron of Tetrahymena thermophila and the processing of pre‐tRNA molecules by RNase P.