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A biochemical pathway for a cellular behaviour: pH i , phosphorylcreatine shuttles, and sperm motility
Author(s) -
Shapiro Bennett M.,
Tombes Robert M.
Publication year - 1985
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950030303
Subject(s) - motility , respiration , sperm motility , sperm , microbiology and biotechnology , mitochondrion , cellular respiration , biology , biochemistry , intracellular , sperm cell , metabolism , chemistry , biophysics , anatomy , genetics
Sperm motility and respiration are tightly coupled processes, both activated by an increased intracellular pH (pH i ). As the sperm pH i increases, the flagellar motor driving motility is activated, leading to ATP consumption. Energy for motility is provided by mitochondrial respiration; energy transport from sperm mitochondrion to tail involves distinct isozymes of creatine kinase that effect a phosphorylcreatine shuttle. The activation of sperm motility and respiration can be described as a linked series of biochemical reactions that form a cell behavioural pathway analogous to the reaction sequences of intermediary metabolism.