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Eukaryotic DNA replication
Author(s) -
Denhardt David T.,
Faust Emanuel A.
Publication year - 1985
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950020403
Subject(s) - primase , eukaryotic dna replication , dna replication , biology , pre replication complex , replisome , origin recognition complex , dna polymerase , replication (statistics) , control of chromosome duplication , genetics , microbiology and biotechnology , dna , gene , polymerase chain reaction , virology , reverse transcriptase
Several factors are contributing to an increased air of excitement about the eukaryotic DNA replication problem: new insights into the nature of origins of replication, a better appreciation of the factors that control initiation, and studies of a DNA polymerase α‐primase enzyme complex. In this review, recent research on the initiation, elongation and termination phases of DNA replication is critically examined and a coherent picture is formulated. In the not‐far‐distant future we expect to reproduce these processes in biochemically defined systems.
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