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Modulation of cAMP effects by Ca 2+ /calmodulin
Author(s) -
Pallen Catherine J.,
Sharma Rajendra K.,
Wang Jerry H.
Publication year - 1985
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950020306
Subject(s) - calmodulin , second messenger system , cyclic nucleotide phosphodiesterase , phosphodiesterase , calcineurin , microbiology and biotechnology , kinase , protein kinase a , modulation (music) , chemistry , calcium , signal transduction , biology , biophysics , biochemistry , physics , enzyme , medicine , organic chemistry , transplantation , acoustics
The second messenger molecules cAMP and Ca 2+ regulate a large number of eukaryotic cellular events. cAMP acts on protein kinases and Ca 2+ works through a ubiquitous calcium‐binding protein, calmodulin. The two systems are not independent, however, but interact in several important fashions. These interactions, and, in particular, the modulation of the cAMP signal by two Ca 2+ /calmodulin‐regulated proteins, cyclic nucleotide phosphodiesterase and calcineurin, are described here.