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The molecular genetics of the components of complement and autoimmune diseases
Author(s) -
Porter R. R.
Publication year - 1984
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.950010607
Subject(s) - major histocompatibility complex , biology , complement (music) , complement component 2 , complement system , gene , immune system , autoimmune disease , genetics , immunology , computational biology , antibody , classical complement pathway , phenotype , complementation
The molecular components of complement are a major part of the armoury of the mammalian immune system, being required for the lysis of antibody‐targeted cells. Several of the complement proteins are known to be encoded by genes within the major histocompatibility complex (MHC). Molecular analysis of these genes is providing new information on the basis of complement action and the possible roles of this system in autoimmune disease.