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The control of size in animals: insights from selector genes
Author(s) -
Crickmore Michael A.,
Mann Richard S.
Publication year - 2008
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20806
Subject(s) - biology , homeotic gene , computational biology , morphogen , gene , evolutionary biology , control (management) , organ system , computer science , genetics , phenotype , medicine , disease , artificial intelligence , pathology
How size is controlled during animal development remains a fascinating problem despite decades of research. Here we review key concepts in size biology and develop our thesis that much can be learned by studying how different organ sizes are differentially scaled by homeotic selector genes. A common theme from initial studies using this approach is that morphogen pathways are modified in numerous ways by selector genes to effect size control. We integrate these results with other pathways known to regulate organ size in developing a comprehensive model for organ size control. ©2007 Wiley Periodicals, Inc BioEssays 30:843–853, 2008. © 2008 Wiley Periodicals, Inc.