Visualizing new dimensions in  Drosophila  myoblast fusion | Zendy

Richardson Brian | Zendy; Beckett Karen | Zendy; Baylies Mary | Zendy

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Visualizing new dimensions in Drosophila myoblast fusion

Author(s) -

Richardson Brian,

Beckett Karen,

Baylies Mary

Publication year - 2008

Publication title -

bioessays

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.175

H-Index - 184

eISSN - 1521-1878

pISSN - 0265-9247

DOI - 10.1002/bies.20756

Subject(s) - mesoderm , drosophila (subgenus) , biology , somatic cell , microbiology and biotechnology , cell fusion , myocyte , fusion gene , drosophila melanogaster , actin , gene , genetics , evolutionary biology , cell , embryonic stem cell

Over several years, genetic studies in the model system, Drosophila melanogastor , have uncovered genes that when mutated, lead to a block in myoblast fusion. Analyses of these gene products have suggested that Arp2/3‐mediated regulation of the actin cytoskeleton is crucial to myoblast fusion in the fly. Recent advances in imaging in Drosophila embryos, both in fixed and live preparations, have led to a new appreciation of both the three‐dimensional organization of the somatic mesoderm and the cell biology underlying myoblast fusion. BioEssays 30:423–431, 2008. © 2008 Wiley Periodicals, Inc.

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