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Insight into initiator–DNA interactions: a lesson from the archaeal ORC
Author(s) -
Tada Shusuke,
Kundu Lena R.,
Enomoto Takemi
Publication year - 2008
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20726
Subject(s) - dna , dna replication , biology , eukaryotic chromosome fine structure , genetics , computational biology , eukaryotic dna replication , origin recognition complex , replication (statistics) , eukaryotic cell , origin of replication , evolutionary biology , microbiology and biotechnology , cell , telomere , virology
Although initiation of DNA replication is considered to be highly coordinated through multiple protein–DNA and protein–protein interactions, it is poorly understood how particular locations within the eukaryotic chromosome are selected as origins of DNA replication. Here, we discuss recent reports that present structural information on the interaction characteristics of the archaeal orthologues of the eukaryotic origin recognition complex with their cognate binding sequences.1,2 Since the archaeal replication system is postulated as a simplified version of the one in eukaryotes, by analogy, these works provide insights into the functions of the eukaryotic initiator proteins. BioEssays 30:208–211, 2008. © 2008 Wiley Periodicals, Inc.