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Systems biology of transcription control in macrophages
Author(s) -
Ravasi Timothy,
Wells Christine A.,
Hume David A.
Publication year - 2007
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20683
Subject(s) - biology , transcriptome , innate immune system , effector , computational biology , immune system , transcription factor , genome , transcription (linguistics) , microbiology and biotechnology , systems biology , genetics , gene , gene expression , linguistics , philosophy
The study of the mammalian immune system offers many advantages to systems biologists. The cellular components of the mammalian immune system are experimentally tractable; they can be isolated or differentiated from in vivo and ex vivo sources and have an essential role in health and disease. For these reasons, the major effectors cells of the innate immune system, macrophages, have been a particular focus in international genome and transcriptome consortia. Genome‐scale analysis of the transcriptome, and transcription initiation has enabled the construction of predictive models of transcription control in macrophages that identify the points of control (the major nodes of networks) and the ways in which they interact. BioEssays 29:1215–1226, 2007. © 2007 Wiley Periodicals, Inc.