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Lentiviral nuclear import: a complex interplay between virus and host
Author(s) -
De Rijck Jan,
Vandekerckhove Linos,
Christ Frauke,
Debyser Zeger
Publication year - 2007
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20561
Subject(s) - nuclear transport , biology , virus , host (biology) , nuclear pore , virology , covid-19 , microbiology and biotechnology , cell nucleus , genetics , nucleus , medicine , infectious disease (medical specialty) , disease , pathology
Although the capacity to infect non‐dividing cells is a hallmark of lentiviruses, nuclear import is still barely understood. More than 100 research papers have been dedicated to this topic during the last 15 years, yet, more questions have been raised than answers. The signal‐facilitating translocation of the viral preintegration complex (PIC) through the nuclear pore complex (NPC) remains unknown. It is clear, however, that nuclear import is the result of a complex interplay between viral and cellular components. In this review, we discuss the current knowledge on nuclear import. We focus on the controversies and pitfalls and discuss the interplay between virus and host. BioEssays 29:441–451, 2007. © 2007 Wiley Periodicals, Inc.