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GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
Author(s) -
Bustelo Xosé R.,
Sauzeau Vincent,
Berenjeno Inmaculada M.
Publication year - 2007
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20558
Subject(s) - gtpase , microbiology and biotechnology , cytoskeleton , effector , biology , gtp binding protein regulators , cell polarity , gtpase activating protein , gtp' , rab , ras superfamily , rac gtp binding proteins , signal transduction , cell , g protein , genetics , rac1 , biochemistry , enzyme
Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family. BioEssays 29:356–370, 2007. © 2007 Wiley Periodicals, Inc.