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Chromatin looping mediates boundary element promoter interactions
Author(s) -
Celniker Susan E.,
Drewell Robert A.
Publication year - 2007
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20520
Subject(s) - enhancer , chromatin , biology , drosophila melanogaster , regulation of gene expression , genetics , regulatory sequence , gene , chia pet , microbiology and biotechnology , gene expression , nucleosome
One facet of the control of gene expression is long‐range promoter regulation by distant enhancers. It is an important component of the regulation of genes that control metazoan development and has been appreciated for some time but the molecular mechanisms underlying this regulation have remained poorly understood. A recent study by Cleard and colleagues1 reports the first in vivo evidence of chromatin looping and boundary element promoter interaction. Specifically, they studied the function of a boundary element within the cis ‐regulatory region of the Abdominal‐B ( Abd‐B ) gene of Drosophila melanogaster . BioEssays 29: 7–10, 2007. © 2006 Wiley Periodicals, Inc.