Premium
Telomere dysfunction: a new player in radiation sensitivity
Author(s) -
Genescà Anna,
Martín Marta,
Latre Laura,
Soler David,
Pampalona Judit,
Tusell Laura
Publication year - 2006
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20501
Subject(s) - ionizing radiation , radiosensitivity , dna repair , telomere , biology , dna damage , radiation sensitivity , organism , computational biology , function (biology) , radiation exposure , mechanism (biology) , dna , genetics , bioinformatics , microbiology and biotechnology , medicine , radiation therapy , irradiation , physics , nuclear physics , philosophy , epistemology , nuclear medicine
Human individuals often exhibit important differences in their sensitivity to ionising radiation. Extensive literature links radiation sensitivity with impaired DNA repair which is due to a lack of correct functioning in many proteins involved in DNA‐repair pathways and/or in DNA‐damage checkpoint responses. Given that ionising radiation is an important and widespread diagnostic and therapeutic tool, it is important to investigate further those factors and mechanisms that underlie individual radiosensitivity. Recently, evidence is accumulating that telomere function may well be involved in cellular and organism responses to ionising radiation, broadening still further the currently complex and challenging scenario. BioEssays. BioEssays 28: 1172–1180, 2006. © 2006 Wiley Periodicals, Inc.