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Cell‐type‐specific regulation of RNA polymerase I transcription: a new frontier
Author(s) -
Tseng Hung
Publication year - 2006
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20430
Subject(s) - biology , transcription (linguistics) , rna polymerase iii , ribosomal rna , rna polymerase ii , general transcription factor , rna polymerase i , multicellular organism , transcriptional regulation , microbiology and biotechnology , genetics , transcription factor , rna polymerase , rna , cell , promoter , gene , gene expression , philosophy , linguistics
Ribosomal RNA transcription was one of the first model systems for molecular characterization of a transcription regulatory mechanism and certainly one of the best studied in the widest range of organisms. In multicellular organisms, however, the issue of cell‐type‐specific regulation of rRNA transcription has not been well addressed. Here I propose that a systematic study of cell‐type‐specific regulation of rRNA transcription may reveal new regulatory mechanisms that have not been previously realized. Specifically, issues concerning the cell‐type‐specific requirement for rRNA production, the universality of Pol I transcription complex and the division of rDNA into regulatory subdomains are discussed. BioEssays 28: 719–725, 2006. © 2006 Wiley Periodicals, Inc.