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Proteasome and transcription: a destroyer goes into construction
Author(s) -
Hegde Ashok N.,
Upadhya Sudarshan C.
Publication year - 2006
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20379
Subject(s) - proteasome , transcription (linguistics) , ubiquitin , biology , histone , transcription factor , microbiology and biotechnology , promoter , genetics , gene , gene expression , philosophy , linguistics
The proteasome is a proteolytic complex that is known to degrade proteins marked by the attachment of ubiquitin. Recently, it has become apparent that the proteasome has non‐proteolytic roles. Several studies have implicated the proteasome in the regulation of transcription. A new study now shows that the proteasome facilitates the interaction of a histone acetyltransferase complex with transcriptional activators at active promoters.1 Bioessays 28:235–239, 2006. © 2006 Wiley Periodicals, Inc.