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Notch signaling in hematopoiesis and lymphopoiesis: Lessons from Drosophila
Author(s) -
Radtke Freddy,
Wilson Anne,
MacDonald H. Robson
Publication year - 2005
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20315
Subject(s) - lymphopoiesis , notch signaling pathway , biology , haematopoiesis , organogenesis , microbiology and biotechnology , signal transduction , function (biology) , immunology , genetics , stem cell , gene
The evolutionarily conserved Notch signaling pathway regulates a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. It is involved in embryonic organogenesis as well as in the maintenance of homeostasis of self‐renewing systems. In this article, we review the role of Notch signaling in the hematopoietic system with particular emphasis on lymphocyte development and highlight the similarities in Notch function between Drosophila and mammalian differentiation processes. Recent studies indicating that aberrant NOTCH signaling is frequently linked to the induction of T leukemia in humans will also be discussed. BioEssays 27:1117–1128, 2005. © 2005 Wiley Periodicals, Inc.