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The InsP 3 receptor: its role in neuronal physiology and neurodegeneration
Author(s) -
Banerjee Santanu,
Hasan Gaiti
Publication year - 2005
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20298
Subject(s) - neurodegeneration , biology , receptor , neuroscience , intracellular , cytosol , microbiology and biotechnology , homeostasis , biochemistry , medicine , disease , enzyme
The InsP 3 receptor is a ligand‐gated channel that releases Ca 2+ from intracellular stores in a variety of cell types, including neurons. Genetic studies from vertebrate and invertebrate model systems suggest that coordinated rhythmic motor functions are most susceptible to changes in Ca 2+ release from the InsP 3 receptor. In many cases, the InsP 3 receptor interacts with other signaling mechanisms that control levels of cytosolic Ca 2+ , suggesting that the maintenance of Ca 2+ homeostasis in normal cells could be controlled by the activity of the InsP 3 R. In support of this idea, recent studies show that altered InsP 3 receptor activity can be partially responsible for Ca 2+ dyshomeostasis seen in many neurodegenerative conditions. These observations open new avenues for carrying out genetic and drug screens that target InsP 3 R function in neurodegenerative conditions. BioEssays 27:1035–1047, 2005. © 2005 Wiley Periodicals, Inc.