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Protein‐interaction mapping in search of effective drug targets
Author(s) -
Chaudhuri Amitabha,
Chant John
Publication year - 2005
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20284
Subject(s) - protein interaction networks , computational biology , drug discovery , interaction network , function (biology) , drug , protein–protein interaction , intervention (counseling) , drug target , biology , computer science , neuroscience , bioinformatics , medicine , pharmacology , microbiology and biotechnology , genetics , gene , psychiatry
Signaling complexes and networks are being intensely studied in an attempt to discover pathways that are amenable to therapeutic intervention. A challenge in this search is to understand the effect that the modulation of a target will have on the overall function of a cell and its surrounding neighbors. Protein‐interaction mapping reveals relationships between proteins and their impact on cellular processes and is being used more widely in our understanding of disease mechanisms and their treatment. The review discusses challenges and breakthroughs in this new and evolving area and its impact on medicine. BioEssays 27:958–969, 2005. © 2005 Wiley Periodicals, Inc.