Premium
Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster
Author(s) -
Sattelle D.B.,
Jones A.K.,
Sattelle B.M.,
Matsuda K.,
Reenan R.,
Biggin P.C.
Publication year - 2005
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20207
Subject(s) - drosophila melanogaster , gene , melanogaster , genetics , biology , nicotinic acetylcholine receptor , acetylcholine receptor , receptor
Nicotinic acetylcholine receptors (nAChRs) are important for fast synaptic cholinergic transmission. They are targets of drugs/chemicals for human and animal health as well as for pest control. With the advent of genome sequencing, entire nAChR gene families have now been described for vertebrates and invertebrates. Mostly, these are extensive with a large number of distinct subunits, making possible many nAChR subtypes differing in transmitter affinity, channel conductance, ion selectivity, desensitization, modulation and pharmacology. The smallest nAChR gene family to date is that of the fruit fly, Drosophila melanogaster , with only 10 members. This apparently compact family belies its true diversity as 4 of the 10 subunits show alternative splicing. Also, using Drosophila , A‐to‐I pre‐mRNA editing has been demonstrated for the first time in nAChRs. Such is the extent of this variation, that one subunit alone (Dα6) can potentially generate far more isoforms than seen in entire gene families from other species. We present here three‐dimensional models constructed for insect nAChRs, which show that many variations introduced by alternative splicing and RNA editing may influence receptor function. BioEssays 27:366–376, 2005. © 2005 Wiley periodicals, Inc.