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How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?
Author(s) -
Adler Christina Jane,
Cao KimAnh Lê,
Hughes Toby,
Kumar Piyush,
Austin Christine
Publication year - 2021
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.202000314
Subject(s) - microbiome , exposome , oral microbiome , oral health , medicine , psychological intervention , environmental health , early childhood caries , physiology , biology , bioinformatics , dentistry , psychiatry
Abstract The first 1000 days of life, from conception to 2 years, are a critical window for the influence of environmental exposures on the assembly of the oral microbiome, which is the precursor to dental caries (decay), one of the most prevalent microbially induced disorders worldwide. While it is known that the human microbiome is susceptible to environmental exposures, there is limited understanding of the impact of prenatal and early childhood exposures on the oral microbiome trajectory and oral health. A barrier has been the lack of technology to directly measure the foetal "exposome", which includes nutritional and toxic exposures crossing the placenta. Another barrier has been the lack of statistical methods to account for the high dimensional data generated by‐omic assays. Through identifying which early life exposures influence the oral microbiome and modify oral health, these findings can be translated into interventions to reduce dental decay prevalence.