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BioEssays 6∕2019
Author(s) -
Piontkivska Helen,
Plonski NoelMarie,
Miyamoto Michael M.,
Wayne Marta L.
Publication year - 2019
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201970061
Subject(s) - adar , zika virus , rna editing , biology , transcriptome , pathogenesis , innate immune system , rna , virology , guillain barre syndrome , genetics , immune system , virus , neuroscience , immunology , gene , gene expression
Adenosine Deaminases Acting on RNA (ADARs) enzymes are prominent regulators of neural transcriptome diversity and play a role in the innate immune response. In article number 1800239, Piontkivska et al. outline how neurodevelopmental and neurodegenerative pathogenesis of Zika virus (ZIKV), including congenital Zika and Guillain‐Barré syndromes, can be attributed to ADAR editing dysregulation triggered by ZIKV, Explaining Pathogenicity of Congenital Zika and Guillain‐Barré Syndromes: Does Dysregulation of RNA Editing Play a Role? DOI: 10.1002/bies.201800239 .