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Trehalose against Alzheimer's Disease: Insights into a Potential Therapy
Author(s) -
Khalifeh Masoomeh,
Read Morgayn I.,
Barreto George E.,
Sahebkar Amirhossein
Publication year - 2020
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201900195
Subject(s) - trehalose , autophagy , neuroprotection , neurodegeneration , disease , chemical chaperone , biology , alzheimer's disease , neuroscience , medicine , biochemistry , unfolded protein response , pathology , apoptosis , endoplasmic reticulum
Trehalose is a natural disaccharide with a remarkable ability to stabilize biomolecules. In recent years, trehalose has received growing attention as a neuroprotective molecule and has been tested in experimental models for different neurodegenerative diseases. Although the underlying neuroprotective mechanism of trehalose's action is unclear, one of the most important hypotheses is autophagy induction. The chaperone‐like activity of trehalose and the ability to modulate inflammatory responses has also been reported. There is compelling evidence that the dysfunction of autophagy and aggregation of misfolded proteins contribute to the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. Therefore, given the linking between trehalose and autophagy induction, it appears to be a promising therapy for AD. Herein, the published studies concerning the use of trehalose as a potential therapy for AD are summarized, providing a rationale for applying trehalose to reduce Alzheimer's pathology.