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Nutrient Sensing and Response Drive Developmental Progression in Caenorhabditis elegans
Author(s) -
Rashid Sabih,
Pho Kim B.,
Mesbahi Hiva,
MacNeil Lesley T.
Publication year - 2020
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201900194
Subject(s) - caenorhabditis elegans , biology , nutrient sensing , nutrient , developmental biology , essential nutrient , microbiology and biotechnology , neuroscience , signal transduction , genetics , ecology , gene
In response to nutrient limitation, many animals, including Caenorhabditis elegans , slow or arrest their development. This process requires mechanisms that sense essential nutrients and induce appropriate responses. When faced with nutrient limitation, C. elegans can induce both short and long‐term survival strategies, including larval arrest, decreased developmental rate, and dauer formation. To select the most advantageous strategy, information from many different sensors must be integrated into signaling pathways, including target of rapamycin (TOR) and insulin, that regulate developmental progression. Here, how nutrient information is sensed and integrated into developmental decisions that determine developmental rate and progression in C. elegans is reviewed.