Premium
Nucleotide Excision Repair and Transcription‐Associated Genome Instability
Author(s) -
Apostolou Zivkos,
Chatzinikolaou Georgia,
Stratigi Kalliopi,
Garinis George A.
Publication year - 2019
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201800201
Subject(s) - nucleotide excision repair , biology , dna repair , genome instability , chromatin , transcription (linguistics) , genetics , dna damage , dna , microbiology and biotechnology , genome , computational biology , gene , linguistics , philosophy
Transcription is a potential threat to genome integrity, and transcription‐associated DNA damage must be repaired for proper messenger RNA (mRNA) synthesis and for cells to transmit their genome intact into progeny. For a wide range of structurally diverse DNA lesions, cells employ the highly conserved nucleotide excision repair (NER) pathway to restore their genome back to its native form. Recent evidence suggests that NER factors function, in addition to the canonical DNA repair mechanism, in processes that facilitate mRNA synthesis or shape the 3D chromatin architecture. Here, these findings are critically discussed and a working model that explains the puzzling clinical heterogeneity of NER syndromes highlighting the relevance of physiological, transcription‐associated DNA damage to mammalian development and disease is proposed.