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Known Unknowns of Mammalian Mitochondrial DNA Maintenance
Author(s) -
Pohjoismäki Jaakko L. O.,
Forslund Josefin M. E.,
Goffart Steffi,
TorregrosaMuñumer Rubén,
Wanrooij Sjoerd
Publication year - 2018
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201800102
Subject(s) - mitochondrial dna , biology , replication (statistics) , dna replication , genetics , computational biology , dna , microbiology and biotechnology , gene , virology
Mammalian mitochondrial DNA (mtDNA) replication and repair have been studied intensively for the last 50 years. Although recently advances in elucidating the molecular mechanisms of mtDNA maintenance and the proteins involved in these have been made, there are disturbing gaps between the existing theoretical models and experimental observations. Conflicting data and hypotheses exist about the role of RNA and ribonucleotides in mtDNA replication, but also about the priming of replication and the formation of pathological rearrangements. In the presented review, we have attempted to match these loose ends and draft consensus where it can be found, while identifying outstanding issues for future research.