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BioEssays 8∕2017
Publication year - 2017
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201770095
Subject(s) - okazaki fragments , dna replication , dna polymerase , biology , genetics , dna , eukaryotic dna replication
Precarious maintenance of simple DNA repeats in eukaryotes: In article number 1700077 , Sergei M. Mirkin and co‐workers present a model for replication fork uncoupling at expandable (GAA) n repeats responsible for Friedreich's ataxia. Lagging strand synthesis by DNA polymerase δ (blue oval) is stalled when the repetitive 5‵‐flap of an Okazaki fragment (green strand) folds forward forming a triplex with the downstream duplex. This may prompt Pol δ to switch templates to the nascent leading strand, resulting in repeat expansions.