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Multitasking Ska in Chromosome Segregation: Its Distinct Pools Might Specify Various Functions
Author(s) -
Zhang Qian,
Chen Yujue,
Yang Lu,
Liu Hong
Publication year - 2018
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201700176
Subject(s) - kinetochore , spindle checkpoint , biology , chromosome segregation , microbiology and biotechnology , mitosis , microtubule , spindle apparatus , genetics , chromosome , cell division , gene , cell
The human spindle and kinetochore associated (Ska) complex is required for proper mitotic progression. Extensive studies have demonstrated its important functions in both stable kinetochore‐microtubule interactions and spindle checkpoint silencing. We suggest a model to explain how various Ska functions might be fulfilled by distinct pools of Ska at kinetochores. The Ndc80‐loop pool of Ska is recruited by the Ndc80 loop, or together with some of its flanking sequences, and the recruitment is also dependent on Cdk1‐mediated Ska3 phosphorylation. This pool seems to play a more important role in silencing the spindle checkpoint than stabilizing kinetochore‐microtubule interactions. In contrast, the Ndc80‐N‐terminus pool of Ska is recruited by the N‐terminal domains of Ndc80 and appears to be more important for stabilizing kinetochore‐microtubule interactions. Here, we review and discuss the evidence that supports this model and suggest further experiments to test the functioning mechanisms of the Ska complex.