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Cell Polarity and Notch Signaling: Linked by the E3 Ubiquitin Ligase Neuralized?
Author(s) -
PerezMockus Gantas,
Schweisguth Francois
Publication year - 2017
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201700128
Subject(s) - notch signaling pathway , microbiology and biotechnology , ubiquitin ligase , endocytosis , cell polarity , notch proteins , biology , polarity (international relations) , cell , nedd4 , hes3 signaling axis , cell fate determination , ubiquitin , signal transduction , biochemistry , transcription factor , gene
Notch is a mechanosensitive receptor that requires direct cell–cell contact for its activation. Both the strength and the range of notch signaling depend on the size and geometry of the contact sites between cells. These properties of cell–cell contacts in turn depend on cell shape and polarity. At the molecular level, the E3 ubiquitin ligase Neuralized (Neur) links receptor activation with epithelial cell remodeling. Neur regulates the endocytosis of the Notch ligand Delta (Dl), hence Notch activation. It also targets the apical polarity protein Stardust (Sdt) to promote the endocytosis of the Crumbs complex, thereby contributing to epithelium remodeling. Here, we review the interplay between Notch signaling and cell polarity and discuss the possible significance of linking Notch signaling with epithelial cell polarity via a common regulator.