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Broad Chromatin Domains: An Important Facet of Genome Regulation
Author(s) -
Carelli Francesco N.,
Sharma Garima,
Ahringer Julie
Publication year - 2017
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201700124
Subject(s) - chromatin , biology , histone , genome , chia pet , computational biology , genetics , epigenetics , genomic organization , evolutionary biology , histone modifying enzymes , chromatin remodeling , gene
Chromatin composition differs across the genome, with distinct compositions characterizing regions associated with different properties and functions. Whereas many histone modifications show local enrichment over genes or regulatory elements, marking can also span large genomic intervals defining broad chromatin domains. Here we highlight structural and functional features of chromatin domains marked by histone modifications, with a particular emphasis on the potential roles of H3K27 methylation domains in the organization and regulation of genome activity in metazoans.