Premium
Arranging eukaryotic nuclear DNA polymerases for replication
Author(s) -
Kunkel Thomas A.,
Burgers Peter M. J.
Publication year - 2017
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201700070
Subject(s) - replisome , control of chromosome duplication , dna replication , origin recognition complex , eukaryotic dna replication , biology , pre replication complex , helicase , minichromosome maintenance , genetics , dna polymerase , semiconservative replication , replication factor c , microbiology and biotechnology , computational biology , dna , gene , rna
Biochemical and cryo‐electron microscopy studies have just been published revealing interactions among proteins of the yeast replisome that are important for highly coordinated synthesis of the two DNA strands of the nuclear genome. These studies reveal key interactions important for arranging DNA polymerases α, δ, and ϵ for leading and lagging strand replication. The CMG (Mcm2‐7, Cdc45, GINS) helicase is central to this interaction network. These are but the latest examples of elegant studies performed in the recent past that lead to a much better understanding of how the eukaryotic replication fork achieves efficient DNA replication that is accurate enough to prevent diseases yet allows evolution.