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BioEssays S1/2016
Publication year - 2016
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201670916
Subject(s) - p tefb , biology , citation , interferon regulatory factors , gene , genetics , transcription factor , virology , world wide web , gene expression , computer science , promoter
Positive transcription elongation factor (P‐TEFb) plays an important role in host cell and viral gene expression. Many viruses, including Herpes Simplex Virus 1, have evolved strategies to hijack this key factor via their own regulatory proteins. The central role of P‐TEFb in viral life cycles raises the possibility that Cdk9 inhibitors might be useful antiviral agents. See article “P‐TEFb goes viral” by Justyna Zaborowska, Nur F. Isa and Shona Murphy in this issue.