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BioEssays 12∕2016
Publication year - 2016
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201670121
Subject(s) - basolateral amygdala , glycogenolysis , psychology , neuroscience , amygdala , biology , endocrinology , glycogen
On pages 1266–1273 of this issue, Boury‐Jamot et al. discuss the role of lactate release from astrocytes to neuronsin the formation and maintenance of cocaine memory. The cover depicts how glycogenolysis‐dependent lactate release is essential for mediating intracellular responses underlying long‐term regulation of gene expression required for long‐lasting conditioned responses to cocaine cues. Disrupting glycogenolysis‐induced lactate release from astrocyte in the basolateral amygdala disrupts the expression of downstream factors accounting for synaptic plasticity and memory reconsolidation (pCREB, pERK and pcofilin). The authors thank Jessica Scheurer ( www.sam‐chuv.ch , Lausanne University Hospital) for assistance in the preparation of the figures.