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BioEssays 7∕2016
Publication year - 2016
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201670071
Subject(s) - enhancer , limiting , psychological repression , transcription factor , cover (algebra) , genetics , genome , biology , computational biology , gene , gene expression , mechanical engineering , engineering
On pages 618–626 , Schmidt et al. discuss the concept of cofactor squelching in light of recent evidence from genome‐wide studies indicating that such competition for a limiting amount of coactivators is a general mechanism of transcriptional repression by signal‐dependent transcription factors (TFs). They further discuss how TF cooperativity in so‐called hotspots and super‐enhancers may sensitize these enhancers to cofactor squelching. The cover illustrates how signal dependent TFs can be regarded as the ‘Robin Hoods’ of the genome, redistributing cofactors (gold coins) from the wealthy super‐enhancers (stacks of gold coins). Cover design: Andreas N. Grøntved.