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BioEssays 6∕2016
Publication year - 2016
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201670065
Subject(s) - hindbrain , lamprey , hox gene , enhancer , biology , zebrafish , vertebrate , function (biology) , evolutionary biology , gene , computational biology , genetics , transcription factor , fishery
Evolutionary conservation of hindbrain segmentation in vertebrates. On pages 526–538 of this issue, Parker et al. explore the origin and diversification of the Hox gene regulatory network for vertebrate hindbrain segmentation and patterning. The cover depicts transgenic embryos of three different species – sea lamprey, mouse and zebrafish – expressing fluorescent proteins in the developing hindbrain through the activity of segmentspecific cis‐regulatory elements. Segmental enhancers from mouse and zebrafish can function when introduced into lamprey, highlighting the conservation of this gene regulatory network to the vertebrate base. Photo credits: Hugo Parker and Mark Parrish. Illustration: Mark Miller.