Premium
Pathogen perception by NLRs in plants and animals: Parallel worlds
Author(s) -
Duxbury Zane,
Ma Yan,
Furzer Oliver J.,
Huh Sung Un,
Cevik Volkan,
Jones Jonathan D.G.,
Sarris Panagiotis F.
Publication year - 2016
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201600046
Subject(s) - biology , pathogen , signalling pathways , function (biology) , fungal pathogen , signalling , ectopic expression , signal transduction , microbiology and biotechnology , computational biology , neuroscience , genetics , gene
Intracellular NLR ( N ucleotide‐binding domain and L eucine‐rich R epeat‐containing) receptors are sensitive monitors that detect pathogen invasion of both plant and animal cells. NLRs confer recognition of diverse molecules associated with pathogen invasion. NLRs must exhibit strict intramolecular controls to avoid harmful ectopic activation in the absence of pathogens. Recent discoveries have elucidated the assembly and structure of oligomeric NLR signalling complexes in animals, and provided insights into how these complexes act as scaffolds for signal transduction. In plants, recent advances have provided novel insights into signalling‐competent NLRs, and into the myriad strategies that diverse plant NLRs use to recognise pathogens. Here, we review recent insights into the NLR biology of both animals and plants. By assessing commonalities and differences between kingdoms, we are able to develop a more complete understanding of NLR function.