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Anti‐inflammatory effects of melatonin in multiple sclerosis
Author(s) -
Farez Mauricio F.,
Calandri Ismael L.,
Correale Jorge,
Quintana Francisco J.
Publication year - 2016
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201600018
Subject(s) - melatonin , multiple sclerosis , immune system , foxp3 , immunology , autoimmune disease , autoimmunity , biology , disease , pathogenesis , neuroscience , medicine , antibody
Melatonin is a hormone with complex roles in the pathogenesis of autoimmune disorders. Over the years, it has become clear that melatonin may exacerbate some autoimmune conditions, whereas it alleviates others such as multiple sclerosis. Multiple sclerosis is an autoimmune disorder characterized by a dysregulated immune response directed against the central nervous system. Indeed, the balance between pathogenic CD4 + T cells secreting IFN‐γ (T H 1) or IL‐17 (T H 17); and FoxP3 + regulatory T cells and IL‐10 + type 1 regulatory T cells (Tr1 cells) is thought to play an important role in disease activity. Recent evidence suggests that melatonin ameliorates multiple sclerosis by controlling the balance between effector and regulatory cells, suggesting that melatonin‐triggered signaling pathways are potential targets for therapeutic intervention. Here, we review the available data on the effects of melatonin on immune processes relevant for MS and discuss its therapeutic potential.