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BioEssays 9∕2015
Publication year - 2015
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201570091
Subject(s) - transmembrane domain , transmembrane protein , domain (mathematical analysis) , ligand (biochemistry) , intracellular , extracellular , receptor , cover (algebra) , citation , computer science , computational biology , chemistry , microbiology and biotechnology , biology , world wide web , mathematics , biochemistry , engineering , mechanical engineering , mathematical analysis
Rotate and activate . On pages 959–967 , Ichiro Maruyama proposes a “rotation model” for the activation of transmembrane cell‐surface receptors. Following this model, receptors exist in a dimeric form prior to ligand binding. The extracellular domain (ECD) has a rotationally flexible structure while the intracellular domain (ICD) is relatively stable. Ligand binding stabilizes the flexible ECD and induces conformational changes of the domains. This in turn induces or allows a rotation of the transmembrane domains leading to a rearrangement of the ICD, hence making the ICD flexible for activation of/interaction with cytoplasmic proteins.