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BioEssays 7∕2015
Publication year - 2015
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201570071
Subject(s) - prophase , mitosis , chromatin , citation , condensin , computer science , biology , dna , genetics , computational biology , world wide web , cohesin , meiosis , gene
Pack it tightly . On pages 755–766 Marc Kschonsak and Christian Haering review how chromosomes are condensed before cell division, and which proteins and molecular machines are involved in this process. The authors discuss a three‐step model for the formation of these mitotic chromosomes. The fi rst step, linear chromatin looping, takes place early during prophase and involves condensin II complexes. This is followed by axial compression during late prophase. This second step is accompanied by the action of topoisomerase IIα and the release of cohesion from chromosomes. The third step is lateral compression and requires the action of condensin I complexes. (Background image fromfotolia ‐ nobeastsofi erce.)