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The search and prime hypothesis for growth cone turning
Author(s) -
Andersen Søren S.L.
Publication year - 2005
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20154
Subject(s) - growth cone , microbiology and biotechnology , actin , microtubule , extracellular , intracellular , receptor , biology , biophysics , biochemistry , axon
In the fields of axonal and dendritic guidance, there is now a significant accumulation of knowledge of how extracellular signaling molecules activate their cognate growth cone receptors. Relatively little is known about the subsequent activation of intracellular signaling pathways and actin reorganization, and very little is known about how microtubules (MTs) reorganize during growth cone turning. I hypothesize that dynamic MTs are required in order to catalyze the polarized actin assembly necessary for growth cone turning, that MTs and actin filaments promote each other's assembly through positive feedback, that MT stability is enhanced further through the formation of membrane‐associated MT attachment sites, and that these MT stabilization events subsequently accelerate axonal/dendritic shaft formation. BioEssays 27:86–90, 2005. © 2004 Wiley Periodicals, Inc.