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miRNA‐mediated crosstalk between transcripts: The missing “linc”?
Author(s) -
Tan Jennifer Y.,
Marques Ana C.
Publication year - 2016
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201500148
Subject(s) - crosstalk , biology , microrna , competing endogenous rna , computational biology , transcriptome , intergenic region , gene , genetics , regulation of gene expression , rna , long non coding rna , non coding rna , gene expression , transcription (linguistics) , genome , physics , linguistics , philosophy , optics
Recently, transcriptome‐wide sequencing data have revealed the pervasiveness of intergenic long noncoding RNA (lncRNA) transcription. Subsets of lncRNAs have been demonstrated to crosstalk with and post‐transcriptionally regulate mRNAs in a microRNA (miRNA)‐dependent manner. Referred to as long noncoding competitive endogenous RNAs (lnceRNAs), these transcripts can contribute to diverse aspects of organismal and cellular biology, likely by providing a hitherto unrecognized layer of gene expression regulation. Here, we discuss the biological relevance of post‐transcriptional regulation by lnceRNAs, provide insights on recent advances in the understanding of lnceRNA regulatory networks, and speculate on molecular factors that facilitate miRNA‐dependent crosstalk between lnceRNAs and other transcripts.