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SUMO‐regulated transcription: Challenging the dogma
Author(s) -
Chymkowitch Pierre,
Nguéa P Aurélie,
Enserink Jorrit M.
Publication year - 2015
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201500065
Subject(s) - chromatin , transcription (linguistics) , transcription factor , biology , transcription coregulator , microbiology and biotechnology , ubiquitin , eukaryotic cell , transcriptional regulation , cell , computational biology , genetics , gene , linguistics , philosophy
The small ubiquitin‐like modifier SUMO regulates many aspects of cellular physiology to maintain cell homeostasis, both under normal conditions and during cell stress. Components of the transcriptional apparatus and chromatin are among the most prominent SUMO substrates. The prevailing view is that SUMO serves to repress transcription. However, as we will discuss in this review, this model needs to be refined, because recent studies have revealed that SUMO can also have profound positive effects on transcription.