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Bad luck and cancer: Does evolution spin the wheel of fortune?
Author(s) -
Roche Benjamin,
Ujvari Beata,
Thomas Frédéric
Publication year - 2015
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201500012
Subject(s) - epigenetics , biology , cancer , carcinogenesis , decipher , epigenesis , genetics , disease , evolutionary biology , computational biology , gene , medicine , dna methylation , pathology , gene expression
Cancer is a complex disease, with sophisticated cellular mechanisms as the targets of evolutionary processes driven by random genetic and epigenetic mutations. Oncogenesis is evolutionarily linked to stem cell numbers/mutations and organ/body size; therefore, inter‐disciplinary frameworks across different scales (cellular, tissue, organs and species) are necessary to decipher cancer progression.