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BioEssays 11∕2014
Publication year - 2014
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201470111
Subject(s) - telomere , mitosis , genome instability , cover story , citation , state (computer science) , biology , cell division , genetics , chromosome , genome , dna , cover (algebra) , computer science , computational biology , cell , dna damage , world wide web , gene , engineering , programming language , mechanical engineering
Maintaining genome stability during mitosis. On pages 1054–1061 Anthony Cesare discusses the cellular mechanisms that suppress double strand break repair (DSB) during mitosis. Suppressing this otherwise vital process during cell division seems to prevent the fusion of deprotected telomeres and therefore helps to maintain genomic integrity. Telomeres adopt three distinct protective states in relation to activation of the DNA damage response and DSB repair: closed‐state, intermediate‐state and uncapped‐state telomeres. The cover depicts chromosomes with these different telomere states.