BioEssays 8∕2014

Spatial coordination of phosphorylation during mitotic entry . In mitosis most eukaryotic cells undergo striking structural rearrangements, such as chromosome condensation or nuclear envelope breakdown. On pages 757–765 of this issue, Mónica Alvarez‐Fernández and Marcos Malumbres review recent data on the spatial regulation of mitotic kinases and phosphatases, and its link with the control of the structural changes required for mitosis. Nucleocytoplasmic transport of cell cycle regulators, such as the recently identified Greatwall kinase, is essential for preparing cells for the physical contact between nucleus and cytoplasm in mitosis upon nuclear envelope breakdown. The cover depicts the dynamic interplay between both compartments required for entry into mitosis.