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BioEssays 7∕2014
Publication year - 2014
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201470071
Subject(s) - cover (algebra) , citation , computational biology , computer science , genetics , rna polymerase , rna , biology , world wide web , information retrieval , gene , mechanical engineering , engineering
The pE‐MAP technology allows for functional dissection of macromolecular assemblies by genetic interrogation of point mutants. Application to yeast RNA polymerase II has enabled functional assignment of its regions and uncovered details related to its catalytic activity. On pages 706–713 of this issue, Braberg et al. discuss the key applications of pE‐MAP, as well as its potential use for personalized medicine when extended to human cells. Shown on the cover is RNA polymerase II with mutated residues highlighted as magenta colored spheres and a pE‐MAP in place of the growing RNA strand. Cover by Hannes Braberg et al.