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An extracellular driving force of cell‐shape changes
Author(s) -
Schmidt Otto,
Theopold Ulrich
Publication year - 2004
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.20146
Subject(s) - leverage (statistics) , biophysics , microbiology and biotechnology , mechanism (biology) , cell , cell membrane , curvature , microvesicles , extracellular vesicles , extracellular , endocytosis , membrane , signalling , chemistry , biology , biochemistry , computer science , physics , gene , microrna , geometry , mathematics , quantum mechanics , machine learning
The cellular capacity to internalise objects, involving attachment, engulfment and uptake, exists in virtually all organisms. Many uptake reactions are associated with cell signalling. However, the mechanical forces that form endocytotic vesicles are not known. We propose a ‘leverage‐mediated’ uptake mechanism involving lateral cross‐linking processes on the cell surface that can generate the configurational energy to create an inverse curvature of the membrane. BioEssays 26:1344–1350, 2004. © 2004 Wiley Periodicals, Inc.