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Pre‐birth world and the development of the immune system: Mum's diet affects our adult health
Author(s) -
Ferreira Manuela,
VeigaFernandes Henrique
Publication year - 2014
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201400115
Subject(s) - offspring , immune system , biology , in utero , immunology , vaccination , immunity , pregnancy , embryo , genetics , physiology , fetus
Secondary lymphoid organs form in utero through an inherited and well‐established developmental program. However, maternal non‐heritable features can have a major impact on the gene expression of the embryo, hence influencing the future health of the offspring. Recently, maternal retinoids were shown to regulate the formation of immune structures, shedding light on the role of maternal nutrition in the genetic signature of emergent immune cells. Here we highlight evidence showing how the maternal diet influences the establishment of the immune system, and we also discuss how unbalanced maternal diets may set the response to infection and vaccination in the progeny.