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Staphylococcus aureus chronic and relapsing infections: Evidence of a role for persister cells
Author(s) -
Conlon Brian P.
Publication year - 2014
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201400080
Subject(s) - multidrug tolerance , staphylococcus aureus , antibiotics , microbiology and biotechnology , pathogen , virulence , biology , endocarditis , osteomyelitis , staphylococcal infections , human pathogen , population , methicillin resistant staphylococcus aureus , antibiotic resistance , immune system , immunology , medicine , biofilm , bacteria , biochemistry , surgery , environmental health , gene , genetics
Staphylococcus aureus is an opportunistic pathogen capable of causing a variety of diseases including osteomyelitis, endocarditis, infections of indwelling devices and wound infections. These infections are often chronic and highly recalcitrant to antibiotic treatment. Persister cells appear to be central to this recalcitrance. A multitude of factors contribute to S. aureus virulence and high levels of treatment failure. These include its ability to colonize the skin and nares of the host, its ability to evade the host immune system and its development of resistance to a variety of antibiotics. Less understood is the phenomenon of persister cells and their role in S. aureus infections and treatment outcome. Persister cells occur as a sub‐population of phenotypic variants that are tolerant to antibiotic treatment. This review examines the importance of persisters in chronic and relapsing S. aureus infections and proposes methods for their eradication.