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BioEssays 11∕2013
Publication year - 2013
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201370111
Subject(s) - ectodomain , insulin receptor , receptor , computer science , biology , insulin , endocrinology , genetics , insulin resistance
Unfold, rotate and activate: New insights into insulin receptor activation. On pages 945–954 , Ward et al. review the most recent data on how insulin binds to its receptor and speculate on the ensuing conformational changes that lead to signal transduction within the cell. The cover shows the ectodomain of the insulin receptor (αβ) 2 homodimer (orange/purple). Binding of insulin (represented in cyan) leads to a conformational change within the ectodomain that is as yet only partially understood, ultimately resulting in the activation of the intracellular tyrosine kinase domains.